Autophagy is the body’s natural process of cleaning out damaged cells to make way for healthier ones. As interest in cellular longevity grows, two compounds—Spermidine and Urolithin A—are gaining popularity for their clinically backed ability to trigger autophagy and mitophagy. This article explains how autophagy works, the scientific mechanisms behind these ingredients, and why they’re at the forefront of the 2025 longevity supplement trend. Learn how targeting cellular renewal can support aging health more effectively than traditional antioxidants.