NAD+ is essential for mitochondrial function, energy metabolism, and cellular repair. However, as we age, NAD+ levels decline dramatically—not just due to decreased synthesis, but also increased degradation. One of the main culprits behind this loss is an enzyme called CD38, which consumes NAD+ at a rapid rate. Recent research has shown that Apigenin, a naturally occurring flavonoid, may inhibit CD38 and support NAD+ restoration. This article explores the science behind this mechanism and its potential application in anti-aging supplements.