Polyamines are small organic compounds involved in cellular growth, DNA stability, and autophagy. Among them, Spermidine and Spermine have gained scientific attention for their roles in longevity and healthy aging. While both are naturally occurring in the human body and found in foods like wheat germ, soybeans, and mushrooms, recent research has begun to differentiate their unique effects. This article compares their mechanisms, benefits, and potential applications in anti-aging supplementation.