Sildenafil Citrate Powder: The Complete 2025 Buyer’s Guide

Introduction

You probably know Sildenafil Citrate as the active ingredient in Viagra®, used to treat erectile dysfunction (ED). But fewer people realize it is also prescribed for pulmonary arterial hypertension (PAH) and even Raynaud’s syndrome, where patients experience painful blood vessel spasms in the fingers and toes. Because of these wider therapeutic applications, the demand for sildenafil citrate powder as an API has steadily increased over the past decade (source).

In this guide, we’ll explore what sildenafil citrate powder is, how it works, its pharma applications, quality and manufacturing standards, global suppliers, pricing, and—most importantly—what B2B buyers should consider before purchasing.

What is Sildenafil Citrate Powder?

Sildenafil Citrate is a phosphodiesterase type 5 (PDE5) inhibitor that improves blood circulation by preventing the breakdown of cyclic GMP (cGMP). This results in smooth muscle relaxation and improved blood flow.

CAS number: 171599-83-0
Formula: C22H30N6O4S
Molecular weight: 474.6 g/mol
Half-life: 4–5 hours
Brand names: Viagra®, Revatio®

In bulk powder form, sildenafil citrate is exported globally as a raw pharmaceutical ingredient (API). Pharmaceutical companies use it to manufacture tablets, capsules, oral suspensions, and even research-grade formulations.

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How Does Sildenafil Citrate Work?

The enzyme PDE5 normally breaks down cGMP, a molecule responsible for relaxing smooth muscles. When cGMP is degraded too quickly, blood vessels constrict, leading to ED or circulatory issues.

Sildenafil inhibits PDE5, allowing cGMP to accumulate. The result? Blood vessels dilate, circulation improves, and patients experience better outcomes in ED, PAH, and vascular disorders (source).

📌 Related reading: How to Use Sildenafil Citrate Powder

Medical and Pharma Applications

Erectile Dysfunction (ED)

By age 40, about 40% of men experience ED, and the rate rises to 70% by age 70 (source). Sildenafil citrate is one of the first-line treatments doctors prescribe. It helps patients maintain an erection long enough for satisfactory sexual activity.

Pulmonary Arterial Hypertension (PAH)

PAH is a serious condition where blood pressure in the lungs rises dangerously, straining the heart. Sildenafil helps relax pulmonary arteries and improves exercise capacity. Revatio® (a sildenafil-based drug) is FDA-approved for PAH treatment (source).

Raynaud’s Syndrome

In cold or stressful conditions, Raynaud’s patients suffer numbness and pain due to blood vessel constriction in fingers and toes. Clinical studies have shown sildenafil citrate can reduce attack frequency and severity (source).

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Common Dosage Forms Created from Powder

Pharma companies transform sildenafil powder into different dosage forms:

Tablets (25mg, 50mg, 100mg)
Chewable tablets for easier administration
Flavored jellies for patient convenience
Oral suspensions (customized by pharmacists, stable up to 60 days)
Injections (rare, for PAH patients in critical care)

Manufacturing & Quality Standards

Key Manufacturing Process

At an industrial level, sildenafil citrate is synthesized through a multi-step organic synthesis:

Construction of the pyrazolopyrimidinone scaffold.
Sulfonation with sulfonyl chloride to introduce key functional groups.
Salt formation with citric acid, improving stability and solubility.

Large-scale factories have optimized this route for yields of 75–80%, with tight controls on residual solvents (DMF, toluene) and heavy metals.

Quality Benchmarks

Purity: ≥99% (HPLC)
Moisture: ≤0.5%
Heavy metals: ≤10 ppm
Residual solvents: ICH Q3C compliant
Compliance: WHO-GMP, DMF, CEP, USP/EP/BP monograph standards

📌 For technical documentation, check our Sildenafil Citrate Powder MSDS & Safety Guidelines.

Global Market Trends & Pricing (2025)

China FOB price: $450–$600/kg (≥99% purity, MOQ 1–5 kg)
India FOB price: $500–$700/kg (factories with US DMF/CEP certification)
Europe/US distributor price: $800–$1200/kg (includes compliance & import costs)

Price drivers include purity grade, regulatory filings, minimum order quantity (MOQ), and global raw material fluctuations (source: PharmaCompass 2024).

👉 For full breakdown: Sildenafil Citrate Powder Price 2025: Factors & Regions

Supplier Landscape

China dominates with 70% of exports, led by GMP-certified factories in Zhejiang & Jiangsu.
India focuses more on finished dosage formulations but exports research-grade powder as well.
Europe/US primarily rely on imports due to high manufacturing costs.

Suppliers often package powder in 1–5 kg foil bags or 25 kg fiber drums, shipped via FedEx/DHL under temperature-controlled conditions.

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Storage & Stability

Sildenafil powder is relatively stable under the right conditions:

Store at 2–8°C, in a sealed, moisture-proof container.
Protect from direct sunlight and humidity.
Shelf life: 24–36 months under recommended storage.

For long-term storage guidelines, read Sildenafil Powder Stability & Storage.

Risks & Compliance Considerations

Counterfeit products — substandard purity or adulterated batches.
Incomplete documentation — absence of COA, MSDS, or DMF is a red flag.
Regulatory restrictions — APIs require FDA/EMA/NMPA clearance before import.

To avoid risk, only purchase from GMP-certified sildenafil citrate suppliers with third-party COA verification.

Future Outlook

New indications: studies suggest sildenafil may help treat pulmonary fibrosis and certain cardiovascular conditions (source: Nature Reviews Urology, 2024).
Market dynamics: tadalafil (longer half-life) and vardenafil (fast onset) remain competitors, but sildenafil maintains the largest global market share.
Regulatory tightening: stricter import requirements in the US/EU will pressure suppliers to upgrade GMP/DMF compliance.

Conclusion

Sildenafil Citrate Powder is much more than an ED treatment API. It’s a multi-purpose active ingredient with expanding applications in PAH, Raynaud’s, and potentially new cardiovascular therapies.

For B2B buyers, key takeaways include:

Always verify purity (≥99%) and compliance (DMF, GMP, MSDS).
Factor in MOQ and certification costs when negotiating price.
Build long-term relationships with trusted sildenafil citrate suppliers to ensure stable supply.