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CAS Number | 272786-64-8 |
---|---|
Molecular Formula | C13H15FN2O3S |
Molecular Weight | 298.333 |
Density | 1.5±0.1 g/cm3 |
Boiling point | 479.5±55.0 °C at 760 mmHg |
Flash Point | 243.8±31.5 °C |
Color | White powder |
CAS Number | 272786-64-8 |
---|---|
Molecular Formula | C13H15FN2O3S |
Molecular Weight | 298.333 |
Density | 1.5±0.1 g/cm3 |
Boiling point | 479.5±55.0 °C at 760 mmHg |
Flash Point | 243.8±31.5 °C |
Color | White powder |
Unifiram is a nootropic agent. It increases acetylcholine (ACh) release in the rat cerebral cortex in vivo and induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50 = 27 nM). It does not bind to serotonin (5-HT), dopamine, muscarinic, nicotinic, adrenergic, glutamate, histamine, opioid, or GABA receptors at 1 µM. Unifiram (0.1 mg/kg) improves memory in non-memory-impaired rats in a social learning test. It also prevents memory deficits induced by the anticholinergic agent scopolamine, nicotinic receptor antagonist mecamylamine, GABAB receptor agonist baclofen, or α2-adrenergic receptor agonist clonidine in the passive avoidance test in mice when administered at a dose of 0.01 mg/kg and prevents memory deficits induced by the AMPA/kainate glutamate receptor antagonist NBQX at 0.1 mg/kg.
Synonym: Unifiram; DM232; DM 232; DM-232
IUPAC/Chemical Name: 2-((4-Fluorophenyl)sulfonyl)hexahydropyrrolo(1,2-a)pyrazin-6(2H)-one
InChi Key: SNRTZFZAFBIBJP-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H15FN2O3S/c14-10-1-4-12(5-2-10)20(18,19)15-7-8-16-11(9-15)3-6-13(16)17/h1-2,4-5,11H,3,6-9H2
SMILES Code: O=C1CCC2CN(S(=O)(C3=CC=C(F)C=C3)=O)CCN21
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Chemical Structure
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