Description: 

Tetracyclines are a group of broad-spectrum antibiotics whose general usefulness has been reduced with the onset of antibiotic resistance. Despite this, they remain the treatment of choice for some specific indications. Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex. Tetracyclines also have been found to inhibit matrix metalloproteinases.

Related CAS #: 64-75-5 (HCl)   60-54-8 (free base)

Synonym: Tetracycline HCl; Achromycin; Achromycin V; Hostacyclin; Sustamycin; Tetrabid; Tetracycline; Topicycline.

IUPAC/Chemical Name: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

InChi Key: XMEVHPAGJVLHIG-FMZCEJRJSA-N

InChi Code: InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

SMILES Code: [H][C@@]12C[C@]3(C(C(C4=C(C=CC=C4[C@]3(O)C)O)=O)=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)[H].[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001