| Product Name |
Hyaluronic Acid Powder |
|---|---|
| Source | Microbial fermentation |
| CAS No. | 9004-61-9 |
| Chemical Formula | (C14H21NO11)n |
| Purity | ≥95.0%(Available in different molecular weights) |
| Appearance | White to off-white powder |
| Packing | 1kg/aluminum foil bag, 25kg/drum or customized packaging |
| Apply |
Joint health, skin hydration, anti-aging, ophthalmic solutions |
Hyaluronic Acid is a versatile active ingredient, but its efficacy is highly dependent on its Molecular Weight (MW). Different product specifications are engineered for distinct applications. Below is a detailed comparison and analysis based on mainstream market specifications.
| Specification | Cosmetic-Grade Hyaluronic Acid | Food-Grade Hyaluronic Acid |
|---|---|---|
| Molecular Weight Range | Ultra-Low MW (<50 kDa) Low MW (50-300 kDa) High MW (1,400-1,800 kDa) | Typically High MW (800-1,500 kDa) |
| Primary Applications | Skincare products, serums, face masks, cosmetic raw material | Dietary supplements, functional foods, beverages |
| Key Data & Mechanism | Ultra-Low MW: Penetrates dermis for repair & anti-aging Low MW: Penetrates stratum corneum for long-lasting hydration High MW: Forms a film on skin surface to lock in moisture & protect | Oral Bioavailability: Partially absorbed into the skin and joints after digestion |
| Purity & Safety | Heavy Metal Residue <10 ppm Total Microbial Count <500 CFU/g | Complies with food additive standards. Heavy Metal Residue <3 ppm Total Plate Count <1,000 CFU/g |
| Appearance | White to off-white fine powder, clear & transparent solution | White powder, good solubility |
| Recommended Dosage | 0.05%-0.3% (Serums/Lotions) 0.5%-1.0% (High-performance Masks) | 80-200 mg daily (depending on formulation) |
1. Cosmetic-Grade HA: Precision Skincare by Molecular Weight
The essence of cosmetic-grade HA lies in “precision skincare through molecular weight targeting.” Different MWs play distinct and irreplaceable roles in the skin.
High MW HA (1,400-1,800 kDa)
Mechanism: Forms a breathable, hydrating film on the skin’s surface.
Core Benefits: Instant moisture locking, protection from pollutants, smooth skin texture.
Applications: Moisturizers, primers, and sunscreens for all skin types.
Low MW HA (50-300 kDa)
Mechanism: Penetrates into the deeper layers of the epidermis.
Core Benefits: Long-lasting hydration, skin barrier repair, improved elasticity.
Applications: Essential moisturizing ingredient in serums, lotions, and creams.
Ultra-Low MW HA (<50 kDa)
Mechanism: Capable of penetrating into the dermis.
Core Benefits: Deep repair, stimulates collagen production, reduces wrinkles.
Applications: High-end anti-aging serums, repair concentrates, and efficacy-driven products.
Best Practice: For immediate and profound, long-term results, we recommend a combination of High, Low, and Ultra-Low MW Hyaluronic Acid to create a multi-dimensional, inside-out moisturizing and repair network.
2. Food-Grade HA: Nourishment from Within
Food-grade HA works through oral ingestion. After being broken down and absorbed by the digestive system, it is distributed to tissues like the skin and joints.
Mechanism: Upon ingestion, part of the HA is broken down into small molecules that serve as building blocks for endogenous HA synthesis; some may be absorbed as larger molecules.
Core Benefits:
Skin Health: Increases skin moisture, improves dryness, and enhances skin elasticity.
Joint Support: Lubricates joints, alleviates discomfort, and improves mobility.
Applications: Liquid supplements, softgels, gummies, functional drinks.
If you are a skincare formulator:
For instant hydration and superior feel, choose High MW.
For deep repair and anti-aging, choose Ultra-Low MW.
For a comprehensive moisturizing solution, choose a Multi-MW Blend.
If you are a health supplement manufacturer:
For skin and joint health products, choose Food-Grade High MW Hyaluronic Acid, ensuring full compliance with food safety regulations.
Fermentation-derived, non-animal source for high safety profile
Multiple molecular weight options to meet varied application needs
Meets USP/EP/JP standards
Low endotoxin and heavy metal content
Stable global supply with GMP-certified production
| Specification | Qualified Testing Result | Actual Testing Result | Test Method |
|---|---|---|---|
| Part 1. Physical & Chemical Analysis | |||
| Appearance | White to off-white powder | Complied | Visual |
| Odor | Characteristic | Complied | Organoleptic |
| Assay (On Dry Basis) | ≥95.0% | 96.8% | HPLC/USP |
| Molecular Weight | Customized (e.g., 0.5–2.0 MDa) | 1.3 MDa | GPC |
| Loss on Drying | ≤10.0% | 8.1% | USP <731> |
| pH (1% Solution) | 5.0–8.5 | 6.9 | USP |
| Part 2. Heavy Metal Analysis & Chemical Control | |||
| Total Heavy Metals | ≤10 ppm | Complied | AAS |
| Lead (Pb) | ≤2 ppm | <0.5 ppm | ICP-MS |
| Arsenic (As) | ≤1 ppm | <0.1 ppm | ICP-MS |
| Cadmium (Cd) | ≤1 ppm | <0.05 ppm | ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | <0.01 ppm | ICP-MS |
| Part 3. Microbiological Analysis & Control | |||
| Total Plate Count (cfu/g) | ≤1,000 | <100 | USP <61> |
| Yeast & Mold (cfu/g) | ≤100 | <10 | USP <61> |
| E. coli | Negative | Negative | USP <62> |
| Salmonella (per 25 g) | Negative | Negative | USP <62> |
Nutraceuticals: Joint health supplements, anti-aging formulas
Cosmetics: Moisturizers, serums, masks
Pharmaceuticals: Ophthalmic solutions, intra-articular injections, wound dressings
Functional Foods: Collagen-HA blends for beauty from within
Q: How to make hyaluronic acid serum from powder?
A: Creating a basic serum is straightforward:
Prepare the Water Phase: Add 1 gram of HA powder to 100 ml of distilled water or floral hydrosol (like rose water). This creates a 1% solution—a great starting point for a serum.
Dissolve: Stir slowly and continuously. It will take 30-60 minutes for the HA to fully hydrate and form a clear, gel-like solution.
Add Actives (Optional): Once fully dissolved, you can add other water-soluble actives. A powerful combination is Niacinamide Powder at 2-5% and a few drops of Glycerin for extra humectancy.
Preserve: This step is critical. Add a broad-spectrum cosmetic preservative (like Liquid Germall Plus) at the manufacturer’s recommended rate (typically 0.1-0.5%) to prevent microbial growth.
Package: Store the finished serum in a clean, airtight bottle.
Q: How to mix hyaluronic acid powder? / How to mix it with water?
A: The key is to avoid clumps.
Best Method (Dispersion): Sprinkle the HA powder very slowly over the surface of the water while stirring vigorously with a mini-whisk or magnetic stirrer. Letting it sit for 30+ minutes ensures a smooth, lump-free gel.
Pro Tip: Never dump the powder all at once, as it will form clumps that are nearly impossible to dissolve.
Q: What is the best hyaluronic acid powder?
A: The “best” powder depends on your goal, as molecular weight dictates its function:
| Molecular Weight | Best For | Sensory Feel |
|---|---|---|
| High MW (1,000+ kDa) | Surface-level protection & intense moisture locking. Ideal for creams & lotions. | Silky, slightly filmy. |
| Low MW (50-300 kDa) | Deeper skin hydration and barrier repair. Ideal for serums. | Light, non-sticky. |
| Multi-Molecule Blend | The Ultimate Choice. Combines all benefits for multi-depth hydration from surface to layers below. | Versatile and luxurious. |
For a superior serum, we recommend a Multi-Molecule Blend.
Q: Can I drink hyaluronic acid powder?
A: Yes, but you must use Food-Grade hyaluronic acid powder. Cosmetic-grade powder is not certified for ingestion.
Dosage: A typical supplement dose is 50-150 mg per day.
How to: Mix the powder into water, juice, or a smoothie. It will thicken the liquid slightly.
Q: Can I mix niacinamide powder with hyaluronic acid?
A: Absolutely. This is a powerhouse combination for your skin.
Synergy: Hyaluronic Acid provides intense hydration and plumping, while Niacinamide strengthens the skin barrier, calms inflammation, and refines pores.
How to: You can mix them directly in the same solution. A great formulation is:
1% Hyaluronic Acid Powder (multi-molecule)
5% Niacinamide Powder
94% Distilled Water & Preservative This creates a highly effective, all-in-one hydrating and brightening serum.
1kg/aluminium foil bag, with two plastic bags inside.
Gross Weight: 1.5kg Size: 18cmxH27cm
25kg/fiber drum, with two plastic bags inside.
Gross Weight: 28kg Size: 42cmxH52cm Volume: 0.0625mg/Drum.
DHL / FEDEX / EMS / E-PACKET / BY AIR / BY SEA
1. ≤50kg, Express delivery(DHL /FEDEX) recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.
We will contact you within 1 working day, please pay attention to the email with the suffix “forrest@oriherb.com”.
