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CAS Number | 870888-46-3 |
---|---|
Molecular Formula | C18H18N2O |
Molecular Weight | 278.4 |
Solubility | DMSO: 2 mg/mL, clear |
Storage temperature | −20°C |
Color | white to beige powder |
CAS Number | 870888-46-3 |
---|---|
Molecular Formula | C18H18N2O |
Molecular Weight | 278.4 |
Solubility | DMSO: 2 mg/mL, clear |
Storage temperature | −20°C |
Color | white to beige powder |
AC-262536 is a selective androgen receptor modulator (SARM; Ki = 5.01 nM).1 It is also a partial agonist of the androgen receptor (EC50 = 1.58 nM in a luciferase assay). AC-262536 is selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM. It inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells when used at concentrations of 0.1 and 1 µM. AC-262536 (3, 10, and 30 mg/kg) reduces plasma luteinizing hormone levels and increases levator ani muscle weight, a marker of anabolic activity, in castrated rats. It exhibits smaller increases in prostate gland and seminal vesicle weight, markers of androgenic activity, compared with testosterone in the same model.
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