Introduction
In recent years, pure apigenin powder has moved from being a niche flavonoid in chamomile tea to a high-demand raw material in nutraceuticals, cosmetics, and pharmaceutical research. Extracted primarily from chamomile flowers, parsley, and celery, apigenin is valued for its anti-inflammatory, antioxidant, and calming properties.
Market demand is growing steadily: according to a 2023 report by Grand View Research, the global flavonoids market was valued at USD 1.2 billion in 2022 and is expected to expand at a CAGR of 6–7% through 2030. Within this category, apigenin stands out as one of the most researched flavonoids due to its dual market appeal — as both a functional ingredient in supplements and a compound of interest in cancer and neuroprotection research.
For buyers, the big questions are:
- Where to find reliable apigenin powder suppliers?
- How much does apigenin bulk powder cost in 2025?
- What purity is required for supplements vs research?
- How to verify COA and HPLC reports before import?
This guide provides a comprehensive roadmap: from apigenin powder benefits to 98% purity standards, from global pricing trends to supplier evaluation. Along the way, you’ll find links to deeper resources, such as the Apigenin Powder Benefits: Science-Backed Uses and the Apigenin Powder Price Trends 2025, so you can explore details relevant to your business needs.
What is Apigenin Powder?
Apigenin (4′,5,7-trihydroxyflavone) is a natural plant-derived flavonoid most commonly extracted from chamomile (Matricaria chamomilla). It belongs to the polyphenol family and has been extensively studied for its potential anti-inflammatory, antioxidant, and neuroprotective activities.
- CAS Number: 520-36-5
- Molecular Formula: C15H10O5
- Molecular Weight: ~270.24 g/mol
- Appearance: Yellow crystalline powder
- Solubility: Poorly soluble in water; soluble in ethanol, DMSO
- Purity Grades: 50%–90% plant extracts, ≥98% HPLC-purified apigenin
Most commercial apigenin bulk powder comes in ≥98% purity produced through solvent extraction and HPLC purification, which ensures reliable consistency for both supplement manufacturers and research labs.
Science-Backed Benefits of Apigenin Powder
When buyers search for apigenin powder benefits, they want to understand not only what apigenin can do, but also why it works and how research supports those claims. Unlike many plant extracts marketed with vague promises, apigenin’s benefits are backed by a growing body of peer-reviewed studies.
1. Anti-Inflammatory Properties
- What the research shows: A 2019 study in Frontiers in Pharmacology reported that apigenin significantly reduced pro-inflammatory cytokines (IL-6, TNF-α) in both cell cultures and animal models.
- Why this matters: Chronic inflammation is a root factor in conditions ranging from arthritis to cardiovascular disease. By reducing these inflammatory markers, apigenin bulk powder is attractive for formulating anti-inflammatory supplements.
2. Antioxidant Effects
- What the research shows: According to the Journal of Agricultural and Food Chemistry (2018), apigenin demonstrated strong ROS (reactive oxygen species) scavenging activity, comparable to other flavonoids such as quercetin.
- Why this matters: Oxidative stress accelerates cellular aging and contributes to skin damage. For supplement makers, this means apigenin can support anti-aging formulas; for cosmetic brands, it strengthens claims in skin-brightening and protective creams.
👉 For real-world product examples, see Apigenin Powder Applications & Case Studies.
3. Sleep & Neuroprotective Benefits
- What the research shows: Apigenin binds to benzodiazepine receptors in the brain, which explains the calming effect traditionally associated with chamomile tea. A 2021 Phytotherapy Research trial found improved sleep latency and quality in adults using apigenin-rich extracts.
- Why this matters: This mechanism makes apigenin powder 98% pure an ideal ingredient in natural sleep aid supplements and formulations targeting stress and anxiety management.
4. Potential Anti-Cancer Properties
- What the research shows: A 2020 paper in Molecules showed apigenin could inhibit tumor angiogenesis and induce apoptosis in certain cancer cell lines.
- Why this matters: Although apigenin is not an approved therapy, such findings explain why research-grade apigenin powder is widely used in oncology laboratories exploring flavonoid-based treatments.
5. Skin Health & Cosmetics
- What the research shows: In a 2021 International Journal of Cosmetic Science study, topical formulations containing flavonoids (including apigenin) reduced UV-induced erythema by 22%.
- Why this matters: For cosmetic companies, this positions apigenin as a natural active for UV protection, soothing irritated skin, and anti-aging serums.
📌 Key takeaway: Apigenin’s benefits span multiple markets — supplements, cosmetics, and research. What makes it especially attractive is the scientific mechanism behind each claim, making it easier for brands to market with credibility.
Apigenin Powder 98% Pure: Quality & Verification
When buyers look for apigenin powder 98% pure, they are usually targeting the highest grade material for premium supplements or pharmaceutical research. But what does 98% really mean, why does it matter, and how can you be sure you’re getting it?
Why 98% Purity Matters
- For Research: Clinical and preclinical studies require highly pure inputs to ensure consistent reproducibility. Using low-purity material could alter results.
- For Supplements: Consumers increasingly demand “clean label” ingredients. Highlighting 98% pure apigenin powder allows supplement brands to market quality with confidence.
- For Compliance: Many regulatory agencies (EU, US, Japan) require documentation that proves high-purity ingredients meet pharmacopoeia standards. Lower purity extracts (50–90%) may be acceptable in food use, but not in pharma-related markets.
📌 Example: In the U.S., dietary supplement manufacturers must follow 21 CFR Part 111, which requires ingredient identity and purity testing. A batch that fails purity checks could result in recall or rejection at customs.
How to Verify Purity
- HPLC (High-Performance Liquid Chromatography):
- Industry gold standard.
- A genuine COA (Certificate of Analysis) should include an HPLC chromatogram showing apigenin ≥98%.
- Buyer Tip: Always demand batch-specific HPLC results, not generic templates.
- UV-Vis Spectroscopy:
- A faster, cheaper verification method.
- Useful for in-house spot checks but less precise than HPLC.
- Appearance & Microscopy:
- 98% apigenin powder should appear as a yellow crystalline powder.
- Off-color (brownish) or clumpy texture indicates possible oxidation or contamination.
👉 For a step-by-step guide on how to validate testing, see How to Verify Apigenin Powder Quality: HPLC & COA Guide.
Avoiding Low-Quality or Fake Material
Unfortunately, rising demand has led to cases of adulteration in the apigenin supply chain:
- Some factories dilute with other flavonoids like luteolin or quercetin.
- Lower-grade extracts (50–70%) are mislabeled as “98% pure”.
- Excessive moisture in packaging leads to degradation before delivery.
📌 Case Example: In 2022, a European importer rejected a 25 kg lot labeled 98% apigenin powder after third-party HPLC showed only 72% purity with luteolin contamination. By testing early, the company avoided customs seizure and reputational damage.
Buyer Checklist for Quality Assurance
- Request a sample (100–500 g) before placing bulk orders.
- Require a COA + MSDS + GMP certificate from the supplier.
- Send the sample for third-party HPLC testing before confirming large shipments.
- Confirm packaging includes double-sealed foil bags inside fiber drums, labeled with batch number and manufacturing date.
Market Price & Supply Chain 2025
When evaluating apigenin powder price, buyers often notice dramatic differences between Chinese factories, Indian GMP suppliers, and US/EU distributors. Understanding why these price gaps exist is essential for controlling procurement costs.
Global Price Ranges (2025)
| Region | Small Lots (100 g–1 kg) | Bulk Orders (25+ kg) | Annual Contracts (500+ kg) | Notes |
|---|---|---|---|---|
| China | $80–$120 / 100 g | $400–$600 / kg | $350–$450 / kg | Lowest cost; flexible MOQs |
| India | $100–$150 / 100 g | $500–$700 / kg | $450–$550 / kg | GMP compliance, slower lead time |
| US/EU | $150–$250 / 100 g | $800–$1,200 / kg | Rarely offered | RUO (research use only), high markup |
📌 Interpretation:
- China dominates bulk supply, thanks to local chamomile cultivation and large-scale extraction plants.
- India charges more, but offers better compliance documents for regulated markets.
- US/EU suppliers mainly resell small RUO packs for labs — convenient but very expensive.
👉 For a deeper breakdown of year-over-year pricing, see Apigenin Powder Price Trends 2025: Bulk Market Analysis.
Why Prices Differ
- Raw Material Source
- China has abundant chamomile and parsley fields, lowering input costs by up to 25%.
- India often imports raw botanicals, raising costs.
- Purification & Processing
- Achieving ≥98% HPLC purity requires multiple purification cycles and solvent costs.
- Micronized apigenin (improved dissolution) is priced 5–10% higher.
- Compliance & Documentation
- Suppliers offering GMP, ISO, or DMF documentation usually charge $2–5/kg more, but reduce customs risk.
- Shipping & Logistics
- Air freight (<50 kg): +$20–30/kg, 5–7 days.
- Sea freight (>100 kg): lowest cost, 30–45 days.
- Customs duties: US ~3–5%, EU stricter phytosanitary checks.
Price Trends 2023 → 2025
- China: Stable at $400–$600/kg due to oversupply.
- India: Prices increased 8–12% in two years, driven by compliance upgrades and energy costs.
- US/EU: No price relief; still 2–3x higher than Asia due to distributor markups.
Supply Chain Strategy for Buyers
- For lowest landed cost: Source from China apigenin powder factories. But insist on HPLC data and COA with batch numbers.
- For regulatory markets: India offers better GMP support at a moderate premium.
- For small-scale research: US/EU distributors are convenient, but unsuitable for bulk scaling.
Manufacturers & Suppliers of Apigenin Powder
The apigenin supply chain is highly fragmented. While China dominates bulk production, India focuses on compliance-driven exports, and US/EU suppliers act more as distributors than manufacturers. Understanding each region’s role helps buyers make smarter sourcing decisions.
1. China: Largest & Most Cost-Effective Base
- Strengths:
- Controls much of the chamomile and parsley cultivation, reducing raw material costs.
- Large extraction facilities with HPLC purification capacity for ≥98% pure apigenin powder.
- Flexible MOQs: from 1 kg lab packs to 500 kg bulk drums.
- Limitations:
- Quality inconsistency among smaller factories.
- Some suppliers provide generic COAs not tied to specific batches.
👉 Best for: Nutraceutical brands and wholesalers looking for cost efficiency in bulk orders.
2. India: Compliance-Focused Exporters
- Strengths:
- Suppliers emphasize GMP, ISO, and export compliance.
- Stronger presence in pharma-grade extracts and regulated market exports.
- Trusted partners for companies selling to US/EU dietary supplement markets.
- Limitations:
- Higher pricing ($500–700/kg bulk vs $400–600/kg in China).
- Longer production lead times (often 4–6 weeks).
👉 Best for: Pharmaceutical R&D and supplement brands requiring tight regulatory documentation.
3. US/EU: Distributors, Not Primary Manufacturers
- Strengths:
- Offer small research packs (100 g – 1 kg) with fast shipping.
- Easy customs clearance within domestic markets.
- Limitations:
- High markup: $800–1,200/kg for ≥98% apigenin.
- Not viable for large commercial contracts.
👉 Best for: Research labs and CROs running small pilot studies.
5-Step Supplier Selection Method
To avoid costly mistakes, buyers should follow a structured evaluation process:
- Document Review
- Request COA, MSDS, GMP, ISO.
- Reject suppliers who only provide “template specs” without batch details.
- Sample Testing
- Order 100–500 g samples.
- Verify with third-party HPLC before scaling orders.
- Factory Audit
- Request virtual tours, QC lab photos, or ISO audit certificates.
- Confirm ability to provide batch traceability.
- Compliance Check
- For pharma: look for DMF or CEP filings.
- For supplements: ensure supplier meets 21 CFR Part 111 (US) or EFSA standards (EU).
- Contract & Logistics
- Negotiate tiered pricing for 25, 100, 500 kg orders.
- Confirm FOB/CIF/DDP terms.
- Insist on proper double-sealed foil packaging in fiber drums.
Applications & Case Studies of Apigenin Powder
Buyers often want more than just technical data — they need to see how apigenin powder bulk is actually applied in real-world products. Below are the key industries and case studies that show apigenin’s market value.
1. Nutraceuticals & Dietary Supplements
- How it’s used:
Apigenin is formulated into sleep aids, anti-anxiety supplements, and healthy aging formulas. Its calming properties come from binding to benzodiazepine receptors, while its antioxidant activity supports cellular protection. - Supporting data:
A 2021 Phytotherapy Research study confirmed apigenin-rich extracts improved sleep quality and reduced sleep latency in adults. - Case example:
A US-based supplement brand introduced apigenin capsules (100 mg) as part of a sleep blend, sourced from 98% pure apigenin powder. Within one year, it became their third best-selling SKU on Amazon US, reflecting consumer demand for natural sleep support.
👉 For more details, see Apigenin Powder Benefits: Science-Backed Uses.
2. Cosmetics & Skincare
- How it’s used:
Added to anti-aging creams, whitening serums, and soothing gels. Apigenin reduces ROS-induced skin damage and calms inflammation and redness. - Supporting data:
A 2021 International Journal of Cosmetic Science study found that flavonoid-based formulations (including apigenin) reduced UV-induced erythema by 22% in controlled trials. - Case example:
A Korean skincare brand launched a chamomile-based serum fortified with 98% apigenin extract, marketed as a “clean beauty” antioxidant solution. It successfully penetrated the Japanese and European markets, where natural-origin actives are in high demand.
3. Functional Foods & Beverages
- How it’s used:
Apigenin is incorporated into fortified teas, functional beverages, and powder blends. - Market trend:
Statista (2023) projects the functional food market to grow 8% annually through 2030, with botanicals like apigenin gaining traction. - Case example:
A Japanese beverage company launched a stress-relief drink containing standardized apigenin extract from chamomile. Marketed toward office workers, sales grew 18% in the first quarter after launch.
4. Pharmaceutical Research
- How it’s used:
Labs worldwide study apigenin for its anti-cancer, cardiovascular, and neuroprotective properties. While not an approved drug, its ability to modulate apoptosis and reduce oxidative stress makes it valuable in experimental trials. - Supporting data:
A 2020 Molecules paper showed apigenin inhibited tumor angiogenesis and improved endothelial function. - Case example:
A European CRO purchased research-grade apigenin powder 98% pure for oncology screening. Their findings supported further exploration of flavonoids as adjunct therapies.
Key Takeaway
- Nutraceuticals: Apigenin supports sleep and anti-anxiety formulations.
- Cosmetics: Acts as a natural antioxidant for anti-aging and whitening products.
- Functional foods: Boosts “stress-relief” beverage launches.
- Pharma research: Investigated for oncology and neuroprotection.
Across all categories, successful launches show that verified purity and strong supplier documentation are critical to building consumer trust and scaling sales.
Safety, Handling & MSDS Snapshot
Even though apigenin powder is a plant-derived flavonoid and generally regarded as safe, bulk handling requires proper storage, packaging, and documentation to ensure stability and compliance.
Storage Guidelines
- Temperature: Store at 2–8°C.
- Why: Heat accelerates oxidation, reducing apigenin purity.
- Packaging: Double-sealed aluminum foil bags inside fiber drums.
- Why: Protects against light, air, and moisture, the main causes of degradation.
- Humidity Control: Use desiccant packs.
- Why: Prevents clumping and microbial growth.
- Shelf Life: 24–36 months if properly sealed.
👉 If powder shows browning or clumping, it may be degraded — request a fresh COA before using.
Handling Precautions
- PPE (Personal Protective Equipment): Gloves, goggles, mask.
- Why: Prevents fine dust inhalation and skin/eye irritation.
- Work Area: Handle in a well-ventilated space or fume hood.
- Weighing & Mixing: Use calibrated scoops and precision scales.
- Why: Ensures consistent dosage and avoids contamination.
Transport & Logistics
- Documentation Required: COA, MSDS, packing list, invoice, GMP certificate.
- Air Freight (<50 kg): +$20–30/kg, 5–7 days, faster but costlier.
- Sea Freight (>100 kg): Most economical; 30–45 days transit.
- Customs Notes:
- Not listed as a dangerous good under IATA/IMDG.
- Smooth clearance if accompanied by MSDS + phytosanitary statement.
Disposal Guidelines
- Small Quantities: Absorb with inert material (sand, vermiculite) → chemical waste.
- Large Quantities: Use licensed hazardous waste facilities.
- Why: Prevents environmental contamination.
MSDS Snapshot for Apigenin Powder
- CAS No.: 520-36-5
- Appearance: Yellow crystalline powder
- Stability: Stable under recommended storage conditions
- Hazards: Low toxicity; dust may cause eye, skin, or respiratory irritation
- Precautionary Statements: Avoid inhalation; store in a cool, dry place
Conclusion & Buyer’s Next Steps
Pure apigenin powder has rapidly grown from a traditional chamomile extract into a high-value raw material for nutraceuticals, cosmetics, functional foods, and pharmaceutical research. In 2025, it is no longer just a “nice-to-have” ingredient — it is a scientifically supported flavonoid with proven market applications.
From this guide, you’ve learned:
- Apigenin powder benefits include anti-inflammatory, antioxidant, neuroprotective, and skin-health support — all backed by peer-reviewed studies.
- 98% apigenin powder is the preferred grade for both supplements and research, but it requires HPLC verification to ensure authenticity.
- Market pricing ranges from $350/kg bulk in China to $1,200/kg for RUO packs in US/EU. Price differences are driven by raw materials, processing costs, and compliance documentation.
- Reliable suppliers can be found in China (cost efficiency), India (compliance), and US/EU (distribution), but buyers must follow a 5-step supplier vetting process.
- Safe storage, handling, and MSDS compliance protect product stability and ensure smooth customs clearance.
What Should Buyers Do Next?
If you are sourcing apigenin powder bulk in 2025, here’s the recommended roadmap:
- Start small – Order a sample batch (100–500 g) and confirm purity via independent HPLC.
- Evaluate suppliers – Choose between China for bulk cost savings or India for regulatory trust.
- Scale up wisely – Once verified, move into 25–100 kg wholesale contracts to secure better pricing.
- Plan logistics early – Decide between air freight for speed or sea freight for economy.
Explore Related Buyer Resources
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