Introduction
Every bulk shipment of Tadalafil raw powder (Cialis API) must be accompanied by a Material Safety Data Sheet (MSDS). This document ensures safety during handling, storage, and international transport, and is a key requirement for customs clearance.
This article summarizes Tadalafil powder MSDS details and provides best practices for handling, storage, and transport in 2025.
👉 For sourcing, see Top Tadalafil Powder Manufacturers & Suppliers 2025.
Chemical Identity
- Product Name: Tadalafil
- CAS Number: 171596-29-5
- Molecular Formula: C22H19N3O4
- Molecular Weight: ~389.4 g/mol
- Form: White to off-white crystalline powder
- HS Code: 29339990 (heterocyclic compounds with nitrogen)
Hazard Identification (GHS Classification)
- Acute Toxicity (Oral): Category 4 (harmful if swallowed raw).
- Skin/Eye Irritation: Mild to moderate possible.
- Respiratory Irritation: Avoid inhalation of fine powder.
- Environmental Hazards: Avoid release into water/soil.
⚠️ Note: Tadalafil is not classified as carcinogenic or mutagenic.
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if irritation persists.
- Skin Contact: Wash with soap and water; remove contaminated clothing.
- Eye Contact: Flush with water for 15 minutes; seek medical advice if irritation continues.
- Ingestion: Rinse mouth; do not induce vomiting; seek medical care immediately.
Handling Guidelines
- Personal Protective Equipment (PPE):
- Gloves (nitrile recommended)
- Safety goggles
- Dust mask/respirator (N95 or equivalent)
- Lab coat
- Workplace Controls:
- Use a fume hood or well-ventilated area.
- Minimize dust formation.
- Do not eat, drink, or smoke while handling.
- Operational Practices:
- Use calibrated scoops and scales.
- Keep logs for batch handling and storage.
- Train staff in emergency response procedures.
👉 For verification, see How to Check Tadalafil Powder Quality: USP Standards & COA.
Storage Guidelines
- Temperature: Store at 2–8°C.
- Packaging: Double-sealed aluminum foil bags inside fiber drums.
- Humidity Control: Use desiccants or silica gel.
- Light Protection: Keep away from direct sunlight.
- Shelf Life: 24–36 months under proper storage.
⚠️ Degraded powder may turn yellowish or clump — indicating reduced potency.
Transportation Guidelines
- UN Classification: Not listed as a dangerous good (IATA/IMDG).
- Required Documents: COA, MSDS, GMP certificate, invoice, packing list.
- Methods:
- Air Freight (<50 kg): Fast but adds $20–30/kg.
- Sea Freight (>100 kg): Cheapest for bulk (30–45 days).
- Customs Risk: Missing MSDS or incomplete COA = delays or seizure.
👉 For price planning, see Tadalafil Powder Price Trends 2025.
Disposal Guidelines
- Small Quantities: Absorb with inert material (sand, vermiculite), dispose as chemical waste.
- Bulk Quantities: Use licensed hazardous waste disposal services.
- Environmental Protection: Do not release into drains, soil, or waterways.
Buyer Red Flags
- Supplier refuses to provide MSDS upfront.
- Packaging not sealed (single plastic bags).
- Labels missing batch number, CAS, or storage instructions.
- Export paperwork missing HS Code.
Conclusion
MSDS compliance is essential for Tadalafil powder handling and international trade.
Key Takeaways:
- Always use PPE and workplace controls.
- Store at 2–8°C in sealed foil bags + fiber drums.
- Ship with COA, GMP, MSDS to ensure customs clearance.
- Dispose through certified hazardous waste channels.
📌 Next Steps:
- Small-lot sourcing
- Bulk contracts
- Supplier vetting
By following MSDS guidelines and requiring full documentation from suppliers, buyers can maintain a safe, compliant, and reliable Tadalafil supply chain.