Introduction
Dapoxetine Hydrochloride (HCl) is a unique pharmaceutical raw material developed specifically for the treatment of premature ejaculation (PE) in men. Unlike conventional selective serotonin reuptake inhibitors (SSRIs), which are prescribed daily for depression and anxiety, Dapoxetine is short-acting — designed for on-demand use before sexual activity.
For manufacturers, researchers, and wholesale buyers, understanding the chemical profile, mechanism of action, and potential applications of Dapoxetine powder is critical before sourcing.
👉 If you’re looking for procurement options, see our Complete 2025 Buyer’s Guide to Dapoxetine HCl Powder.
Chemical Identity & Properties
- Chemical Name: Dapoxetine Hydrochloride
- CAS Number: 129938-20-1
- Molecular Formula: C21H23NO·HCl
- Molecular Weight: 341.9 g/mol (free base), ~372.9 g/mol (HCl salt)
- Appearance: White to off-white crystalline powder
- Solubility: Freely soluble in methanol and ethanol; sparingly soluble in water
- Storage: Stable under dry, cool conditions (2–8°C); moisture sensitive
👉 For safety handling and storage details, see Dapoxetine MSDS & Safety Guidelines.
Mechanism of Action
Dapoxetine belongs to the SSRI (Selective Serotonin Reuptake Inhibitor) class. However, unlike other SSRIs (fluoxetine, paroxetine, sertraline), which are long-acting and require weeks to reach steady-state, Dapoxetine works within 1–2 hours of ingestion and clears the body within 24 hours.
- How it works:
- Inhibits serotonin transporter → increases serotonin activity in synaptic clefts.
- Prolongs latency of ejaculation by modulating central nervous system pathways.
- Improves sense of control and reduces PE-related distress.
📊 Clinical trials show Dapoxetine can increase intravaginal ejaculatory latency time (IELT) by 2–3 fold compared to placebo.
Approved Clinical Use
- Indication: Treatment of premature ejaculation (PE) in men aged 18–64.
- Typical Dosage: 30 mg or 60 mg tablet, taken 1–3 hours before intercourse.
- Brand Name: Marketed as Priligy in many countries.
- Status: Approved in Europe, Asia, Middle East, and parts of Latin America. Not FDA-approved in the US (research only).
👉 For a comparison with consumer tablets, see Dapoxetine Powder vs Tablets: What Buyers Should Know.
Pharmaceutical Applications
- Premature Ejaculation (PE):
- Primary use, with demonstrated efficacy and tolerability.
- Combination Therapies:
- Studied in combination with PDE5 inhibitors (e.g., Sildenafil, Tadalafil) for men with both PE and erectile dysfunction (ED).
- Compounding Pharmacies:
- In certain jurisdictions, Dapoxetine powder is compounded into customized dosages or liquid suspensions for patient-specific needs.
Research Applications
Beyond approved use, research-grade Dapoxetine powder is used in laboratories for:
- CNS and neuropharmacology studies: Understanding short-acting SSRI dynamics.
- Animal models: Testing ejaculation control pathways.
- Formulation research: Developing orally disintegrating tablets (ODTs) or novel suspension liquids.
- Comparative pharmacology: Evaluating Dapoxetine alongside longer-acting SSRIs.
👉 For RUO (Research Use Only) lots, see Research-Grade Dapoxetine Applications.
Safety & Side Effects
Like other SSRIs, Dapoxetine may cause:
- Common side effects: Nausea, headache, dizziness, insomnia.
- Less common: Fatigue, mild anxiety, gastrointestinal upset.
- Serious but rare: Syncope (fainting), serotonin syndrome if combined with other serotonergic drugs.
Precautions:
- Not recommended with MAOIs, thioridazine, or SSRIs/SNRIs due to serotonin syndrome risk.
- Use with caution in patients with cardiovascular conditions.
Market Outlook (2025)
- Growing acceptance in Europe, Asia, Middle East.
- Increasing use in combination therapies with ED treatments.
- Ongoing interest in generic API production in China and India.
- Expanding research applications in short-acting SSRI models.
👉 For supplier comparisons, see Top Dapoxetine Manufacturers & Suppliers 2025.
Conclusion
Dapoxetine HCl powder is a specialized SSRI raw material, unique for its short-acting properties and role in PE treatment. For buyers, it represents both a growing pharmaceutical market opportunity and a research asset.
Key takeaways:
- Mechanism: Short-acting SSRI → serotonin modulation → delayed ejaculation.
- Applications: PE treatment, combination therapies, compounding, CNS research.
- Market: Strong supply base in China & India, growing global demand.
📌 Next Steps:
- Trial sourcing → Buy Dapoxetine Powder Online
- Scale contracts
- Verify compliance → Dapoxetine MSDS & Safety Guidelines