This article is targeted at pharmaceutical R&D teams, compounding pharmacies, and nutraceutical OEMs who want to understand applications, preparation methods, and handling of sildenafil citrate powder. It will keep the narrative + practical style, with internal links back to the Pillar and related transactional/trust pages.
Introduction
Sildenafil Citrate is best known as the active ingredient in Viagra®, but in its raw form—sildenafil citrate powder—it is the foundation of multiple pharmaceutical formulations. Companies and pharmacies use the powder for oral suspensions, capsule and tablet compounding, chewable forms, and even experimental research applications.
For B2B buyers, knowing how sildenafil citrate powder is used in real-world formulations is essential for planning procurement, stability testing, and compliance documentation.
👉 If you are just starting, see the Complete Buyer’s Guide to Sildenafil Citrate Powder for an overview of sourcing and market trends.
Common Dosage Forms Made from Powder
1. Standard Tablets & Capsules
- Most common form: 25 mg, 50 mg, or 100 mg tablets.
- Applications: Erectile Dysfunction (ED) and Pulmonary Arterial Hypertension (PAH).
- Notes: Requires excipients for binding and controlled release.
2. Chewable Tablets
- Increasingly popular for patients with swallowing difficulties.
- Produced by blending sildenafil powder with flavoring and sweeteners.
3. Oral Suspension / Solution
- Useful for pediatric PAH or geriatric patients.
- Typical concentration: 1 mg/mL or 2 mg/mL.
- Requires preservatives (sodium benzoate, parabens) for stability.
- Stability: Up to 60 days refrigerated (2–8°C) (source: FDA Revatio® prescribing info).
👉 More on stability: How Long Does Sildenafil Powder Last? Storage & Shelf Life
4. Jelly Formulations
- Flavored gels for convenience.
- Particularly common in nutraceutical markets.
5. Injectable Form (rare)
- Used only in hospital/critical care settings for PAH.
- Requires sterile GMP facilities.
Compounding Sildenafil Citrate Powder
Process Overview
- Weighing: Accurate measurement using analytical balance (precision ±0.1 mg).
- Mixing with Excipients: Lactose, microcrystalline cellulose, or other carriers.
- Formulation: Tablet compression, capsule filling, or solution preparation.
- Testing: QC check for uniformity, dissolution, and potency.
Compounding Pharmacies
In the US and EU, licensed pharmacies may use sildenafil citrate powder to prepare customized dosage forms (e.g., oral liquids for patients unable to take tablets).
👉 Buyers sourcing powder for compounding should begin at Buy Sildenafil Citrate Powder Online to ensure small-lot GMP supply.
Measuring and Handling Powder
Accurate Measurement
Because sildenafil dosage is highly sensitive, correct measurement is critical:
- Use calibrated analytical balances.
- Avoid kitchen or generic scales—these lack precision.
- For research, doses are typically diluted into stock solutions to minimize weighing errors.
Handling & Safety
- Always wear gloves and lab coat when handling.
- Use fume hood for large-scale operations.
- Dispose of waste according to MSDS guidelines.
📌 See Sildenafil Citrate Powder MSDS & Safety Guidelines for proper handling procedures.
Dosage Considerations
- Erectile Dysfunction: Typical starting dose is 50 mg, adjustable between 25 mg and 100 mg based on patient response.
- Pulmonary Arterial Hypertension: 20 mg three times daily (Revatio® standard).
- Research Use: Variable, often converted into mg/kg for animal studies.
⚠️ Important: These are reference values for licensed pharmaceutical use. Buyers of raw powder should never sell or market for direct human consumption without GMP processing and regulatory approval.
Stability and Shelf Life
Sildenafil citrate powder is stable if stored under recommended conditions:
- Temperature: 2–8°C
- Moisture control: ≤60% relative humidity
- Packaging: sealed aluminum foil bags, outer fiber drum
- Shelf life: 24–36 months
Improper storage (heat, humidity, sunlight) accelerates degradation, resulting in yellow discoloration and reduced purity.
👉 Learn more in Sildenafil Powder Stability & Storage.
Regulatory & Compliance Aspects
Before using sildenafil powder in any compounding or formulation:
- Ensure supplier provides COA, GMP certificate, DMF/CEP filings.
- Follow FDA 21 CFR Part 210/211 or EU GMP guidelines.
- For nutraceuticals, labeling regulations vary by region (supplement vs. drug classification).
For compliant sourcing, review Top Sildenafil Citrate Powder Suppliers in China & India.
Conclusion
Sildenafil citrate powder is a versatile API, used not only in standard tablets but also in oral suspensions, chewables, gels, and customized compounded preparations. For B2B buyers, understanding these applications helps determine the right purity, packaging, and supplier documentation required.
To recap:
- Compounding requires precise measurement and excipient blending.
- Oral suspensions are stable for up to 60 days refrigerated.
- Long-term supply requires GMP-certified wholesale contracts.
📌 Next steps:
- Start procurement via Buy Sildenafil Citrate Powder for trial lots.
- Ensure compliance with MSDS & Safety Guidelines for safe handling.
By mastering both the technical and compliance aspects of sildenafil powder use, buyers can ensure safe, effective, and profitable product development.