This article examines the challenges of delivering resveratrol orally and how liposomal encapsulation offers a reliable solution. It explains how standard resveratrol degrades rapidly in the digestive tract and is subject to first-pass metabolism, severely limiting its effectiveness. In contrast, liposomal technology enhances bioavailability, stability, and tissue delivery—making it ideal for supplement brands and B2B developers targeting high-performance antioxidants.