One of the most popular testosterones on the planet, mixed testosterone (Sustanon 250), is a game changer in bodybuilding and testosterone therapy.
Manufactured by pharmaceutical giant Organon, Sustanon 250 was designed to create a best-in-class testosterone replacement therapy (TRT) solution for TRT patients who need only one injection of Sustanon 250 per month to alleviate all low testosterone problems (low libido, low confidence, erectile dysfunction, low muscle mass, weak muscle strength)
Of course, Sustanon 250 is quickly becoming the solution for bodybuilders, other athletes, and fitness enthusiasts to enhance their overall performance.
Sustanon 250 can utilize a variety of different-sized esters, but the use of small and large esters creates a unique problem: total testosterone levels will rise and then occasionally or unpredictably fall again.
The lack of need for frequent injections makes Sustanon 250 a popular drug for the treatment of low testosterone disorders. It allows patients to maintain testosterone levels with less frequent injections. But that’s not really the important property of Sustanon 250. Mixed testosterone does not provide better results for athletes than monoester-based testosterone. In order to enhance performance, athletes need frequent injections (such as testosterone propionate) to get a peak in testosterone concentration and not just to keep the concentration constant. Some people always make the mistake of thinking that Sustanon 250 is more effective than other monoester-based testosterone, but it is actually a mixture of four testosterones by the nature of testosterone, all testosterone is equally effective.
Sustanon 250 is made up of four different-sized esters; the different testosterone esters offer different half-lives, and they need to be combined in a very precise way to have the desired impact; as long as any one of them is unbalanced, the benefits of Sustanon 250 will not be realized.
Functions and properties of Sustanon 250
Composition of Sustanon 250.
30 mg propionate
60 mg phenylpropionate
60 mg isocaproate
100 mg decanoate
Sustanon 250 is a multifunctional hormone for both muscle-building and fat-loss cycles, it is the perfect base when stacked with other anabolic steroids, and it is unique in that it allows its four esters to act synergistically with each other to produce fantastic results.
The above figures refer to the amount per ml. It is important to note that Sustanon 250’s ingredients are very similar to Omnadren, which Jelfa produces. The difference is that Omnadren comes with an additional 100 ml of testosterone acetate instead of testosterone decanoate. However, the modern Omnadren formulation contains more decanoate, which is closer to Sustanon 250.
As a testosterone preparation, sunstanon250 is very effective in the treatment of low testosterone, which is important for both men and women, but men need higher levels of testosterone. This hormone not only ensures the normal development of sexual function but also has many links to our health. Testosterone acts on our body, mind, and sexual function, and a low testosterone status can lead to a number of problems. Although not fatal, it can seriously affect the quality of life and mood.
Sunstanon 250 can easily help people with low testosterone to improve the following symptoms:
- loss of sexual desire
- erectile dysfunction
- loss of muscle
- loss of strength
- increased body fat
- mental depression
- lack of energy
- depressed mood
- Decline of the immune system
The use of Sustanon 250 can greatly improve the quality of life of patients. Studies have shown that if low testosterone is not taken seriously, it can lead to a number of more serious diseases.
- Alzheimer’s syndrome (dementia)
- diabetes mellitus
- anxiety disorders
- Heart disease
Interestingly, while high testosterone levels can cause some heart problems, low testosterone causes even more serious problems. If you suffer from low testosterone, there is little reason not to use a powerful and convenient testosterone preparation like sunstanon250 to stay healthy.
Sunstanon250’s properties include the following
Improved protein synthesis efficiency: Improved protein synthesis efficiency means cells begin synthesizing muscle tissue preferentially. This is the most basic anabolic function.
Improved Nitrogen Retention: All muscle tissue contains approximately 16% nitrogen. When nitrogen levels drop, muscle is at risk of loss. The more nitrogen that is retained, the more stable the anabolic environment that is created. This property plays an important role in both the muscle-building cycle and the fat-loss cycle.
Increase the number of red blood cells: Red blood cells are responsible for the transport of oxygen in the blood. And an increase in blood oxygenation increases muscle function, which means that muscle endurance and recovery are greatly enhanced.
Increased insulin-like growth factor: Insulin-like growth factor is a very powerful naturally occurring anabolic substance. An increase in anabolic function can greatly enhance muscle recovery. This substance can affect every cell in the body.
Glucocorticoid Inhibition: Glucocorticoids are the antonym of anabolic steroids. This hormone destroys muscle tissue and causes fat storage. Cortisol is the best-known glucocorticoid. The use of testosterone preparations such as Sustanon 250 ensures that glucocorticoids do not become the dominant hormone in the body.
Effects of sunstanon250
To enhance athletic performance, we need to go over the effects of sunstanon250 in a step-by-step manner.
Using sunstanon250 in the off-season muscle-building cycle is the best option. High doses of testosterone can provide the perfect environment for muscle growth, provided that you consume enough calories. Not eating enough to give you more testosterone won’t have much effect; how do you build a tall building without bricks? Once paired with the perfect diet, however, testosterone can bring about very significant muscle growth.
Testosterone can also boost your metabolic efficiency, which is also important. High testosterone levels will allow you to avoid adding too much body fat in the off-season. But it needs to be made clear that if your diet and nutrition do not do well will always grow body fat, but a sensible diet with testosterone can make your off-season training more efficient.
However, during the fat loss period, Sustanon 250 is also a very good choice; its strong anabolic efficiency can be better than any kind of steroids that are suitable for muscle preservation. When your diet during race preparation ensures that you consume more calories than you take in, muscle is at risk of being depleted. The body will always prioritize the consumption of muscle when it needs energy. It is possible to force the body to prioritize fat consumption through a sensible diet, but there is a limit to this. At a certain point in fat loss, the body will go into self-protection mode and purposely store fat. This is the time when high levels of testosterone should come into play.
Preserving muscle during fat loss is not the only purpose; testosterone can enhance anabolic efficiency and burn fat more efficiently. However, it is important to note that the dose of testosterone used during the fat-loss phase is less than the dose used during the muscle-building phase, which will be further analyzed when the side effects are described below. It is never a good idea to have low testosterone levels during fat loss; you need to understand how much testosterone you need to gain muscle and at least the same dose to maintain muscle. Of course, you can also lower your testosterone dosage while pairing it with other different medications.
High doses of testosterone can also improve muscle recovery and muscle endurance. And the recovery process is the process of muscle growth, not the hour or two of training in the gym. By its very nature, training tears muscle fibers and muscle growth means the recovery of torn cells. High doses of testosterone can make this process faster and more efficient. Of course, Sustanon 250 also boosts the user’s strength, which is important for training.
Testosterone is readily aromatized to estradiol (estrogen) in the body. Aromatase (estrogen synthase) is responsible for testosterone metabolism. Elevated estrogen levels can cause side effects, such as increased water storage, body fat, and gynecomastia. Testosterone is considered to be a moderately estrogenic steroid. Anti-estrogens such as clomiphene or tamoxifen are necessary to prevent estrogenic side effects. One may also use aromatase inhibitors, such as anastrozole, which are more effective in controlling estrogen by preventing its synthesis. However, aromatase inhibitors can be expensive compared to anti-estrogens and may also harm blood lipids.
Estrogen side effects can occur at high or low doses, and high doses (above normal therapeutic levels) of testosterone may require the concomitant use of anti-estrogens or aromatase inhibitors. Since water storage and muscle loss are common for higher doses of testosterone, the drug is often considered a poor choice for the dieting or cutting phase. Its moderate estrogenicity makes it more appropriate for the weight gain phase, where the stored water will provide the original strength and size of the muscle and help provide a stronger anabolic environment.
Testosterone is the primary male androgen responsible for the maintenance of male secondary sexual characteristics. Elevated testosterone levels may produce androgenic side effects, including oily skin, acne, and body/facial hair growth. Men genetically predisposed to hair loss (androgenetic alopecia) may notice accelerated baldness. Those concerned about hair loss may find a more comfortable alternative in nandrolone, a relatively less androgenic steroid. Women are also exposed to the potential pathogenic effects of anabolic/androgenic steroids, especially strong androgens such as testosterone. These side effects may include voice deepening, irregular menstruation, skin texture changes, facial hair growth, and clitoral enlargement.
The high relative androgenicity of testosterone in androgen-responsive target tissues such as the skin, scalp, and prostate depends on its reduction to dihydrotestosterone (DHT). 5-alpha reductase is the main cause of testosterone metabolism. The concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride interferes with the site-specificity of testosterone action and reduces the propensity of testosterone drugs to produce androgenic side effects. It is important to remember that both anabolic and androgenic actions are mediated through the androgen receptor. Complete separation of testosterone’s anabolic and androgenic effects is impossible, even if all 5-alpha reductases are inhibited.
Testosterone has no hepatotoxic effects; therefore, the development of hepatotoxicity is unlikely. One study examined the hepatotoxic potential of high doses of testosterone by administering 400 mg of the hormone daily (2,800 mg per week) to a group of male subjects. Oral steroids can reach higher peak concentrations in liver tissue than intramuscular injections. Hepatic enzyme values, including serum albumin, bilirubin, alanine-aminotransferase, and alkaline phosphatase, did not change significantly when the hormone was given daily for 20 days.
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values and may convert HDL to LDL, leading to a greater risk of atherosclerosis. The relative effects of anabolic/androgenic steroids on serum lipids depend on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and cause left ventricular hypertrophy, which may increase cardiovascular disease and myocardial infarction risk.
Testosterone has a much smaller effect on cardiovascular risk factors than anabolic steroids. This is due in part to its openness to hepatic metabolism, making it less likely to affect hepatic cholesterol. The aromatization of testosterone with estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg of testosterone ester (testosterone enanthate) per week had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but a strong (25%) reduction was observed when an aromatase inhibitor was used. With 300 mg of testosterone ester (testosterone enanthate) per week for 20 weeks, the no aromatase inhibitor group showed only a 13% reduction in HDL cholesterol, while at 600 mg, the reduction reached 21%. The negative effects of aromatase inhibition should be considered prior to treatment with testosterone.
Tamoxifen citrate or clomiphene citrate is superior to aromatase inhibitors because of the positive effect of estrogens on serum lipids and because they have a partial estrogenic effect in the liver. This allows them to potentially improve lipid distribution and counteract some of the negative effects of androgens. The effects on lipid profiles tend to be pronounced but not dramatic at doses of 600 mg or less per week, which also makes anti-estrogens (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week also failed to produce statistically significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all of which suggest relatively weak effects on cardiovascular risk factors. When used at moderate doses, injectable testosterone is generally considered to be the safest of all anabolic/androgenic steroids.
To help reduce cardiovascular strain, it is recommended to maintain an active cardiovascular exercise program and to minimize intake of saturated fat, cholesterol, and simple carbohydrates at all times during AAS use. Supplementation with fish oil (4 grams per day) and natural cholesterol/antioxidant formulas such as Lipid Stabil or products with similar ingredients are also recommended.
All anabolic steroids suppress the body’s own production of testosterone. However, since Sustanon 250 was originally a testosterone preparation, there is no problem with this aspect. The real-time to be aware of this aspect is after discontinuation of the drug. After the other exogenous steroid hormones leave your body, your body’s own testosterone production will gradually recover. But the natural recovery process is quite slow, and this can lead to hypotestosteronism, where the cortisol hormone may become the dominant hormone in the body. That’s why a post-cycle PCT recovery process is still necessary. This recovery process will lead to a more rapid recovery of your testosterone levels. A good post-cycle recovery will ensure that your testosterone levels will still allow your body to function properly until they gradually return to normal. This will also speed up testosterone production, but it will still take a few months overall. It is important to note that your natural recovery process is based on the premise that testosterone levels in your body are not too low and that your body’s gonadal axis has not been severely damaged. At the end of a cycle, the initial testosterone levels in the body are so low that glucocorticoids can easily take control of hormone metabolism in the body, and proper post-cycle recovery will do a good job of suppressing this side effect.
Use of Sustanon 250
As a performance-enhancing drug, Sustanon 250 is used at a dose of roughly 250-1000 mg per week, with 250 mg per week providing adequate testosterone coverage when mixed. While 500 mg per week is more recognized as the most effective and tolerated by most men. Some people will use higher doses, but higher doses have more side effects, and 1000 mg per week amplifies them.
Sustanon 250 is not recommended if you have any of the conditions highlighted below.
- High blood pressure
- High cholesterol levels
- Prostate enlargement or high PSA
- Other more serious unhealthy symptoms