Introduction to the functions and side effects of testosterone enanthate


Testosterone Enanthate

Androgen index 100

Anabolic index 100

Estrogenic activity Moderate

Progesterone activity Low

Common forms Injectable oil

Introduction to Testosterone Enanthate:

Testosterone enanthate is a long-acting product in the injectable testosterone class. Following deep intramuscular injection, testosterone enanthate causes a sustained release of testosterone into the bloodstream for approximately 2 to 3 weeks. In order to maintain normal physiological levels of testosterone during androgen replacement therapy (TRT), testosterone enanthate injections are usually required at least every two weeks, with most physicians preferring weekly injections in medical practice. As with all testosterone injections, testosterone enanthate is favored by athletes for its ability to promote strength and growth of muscle mass.

Testosterone enanthate in the medical field:

Testosterone enanthate is most commonly used clinically to maintain the normal levels of testosterone needed by adult men with low androgen levels. Low androgen levels are characterized by low libido, lean body mass, small muscle mass, and daily mental fatigue, and lack of energy. Testosterone enanthate is also used to treat abnormal testicular development and delayed puberty in adolescent males and is occasionally used as a secondary medication during inoperable breast cancer in women. Testosterone enanthate has also been used with great success as a male contraceptive. A study of men in Thailand showed that weekly injections of 200 mg of testosterone enanthate were effective in reducing sperm production in most men over a three-month period, and this suppression continued until the drug was discontinued. To this day, testosterone enanthate remains the most widely used testosterone drug in the world.

Common product specifications for testosterone enanthate:

Testosterone enanthate is widely used in the human and veterinary markets. Formulations and dosages vary by country and manufacturer, with common dosage sizes being 50mg/ml, 100mg/ml, 200mg/ml, or 250mg/ml, and up to 500mg/ml, usually in 10ml syringes or 1ml ampoules.

Structural characteristics of testosterone enanthate:

Testosterone enanthate is a modified form of testosterone in which enanthoic acid has been attached to the 17-beta hydroxyl group. The esterified form of testosterone is less polar than free testosterone and is absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed, and free (active) testosterone is obtained. Esterified forms of testosterone are designed to extend the window of therapeutic effect after administration, and esterified steroid products can be injected less frequently than free (unesterified) steroids. The half-life of testosterone enanthate is approximately eight days after injection.

Testosterone enanthate side effects: (estrogen side effects)

Testosterone is easily aromatized in the body and thus converted to estradiol (estrogen). The enzyme aromatase (estrogen synthase) is responsible for this metabolism of testosterone. Elevated levels of estrogen can cause side effects such as body water storage, increased body fat, and mammary gland development in men (bitch milk). Testosterone is considered to be a moderately estrogenic steroid. Some anti-estrogenic drugs, such as clomiphene or tamoxifen, are necessary to prevent the side effects of elevated estrogen. Alternatively, aromatase inhibitors such as anastrozole (Arimidex) can be used, which are more effective in controlling estrogen by blocking estrogen synthesis. However, aromatase inhibitors are more expensive than anti-estrogen drugs and have a negative impact on blood lipids. The effects of estrogen side effects are generally determined by the level of the dose used, with higher doses (above normal therapeutic levels) of testosterone being more likely to require concomitant use of anti-estrogen or aromatase inhibitors to suppress estrogen levels in the body. The reduction in water storage, body dryness, and muscle definition associated with higher doses of testosterone is common, so this testosterone enanthate is generally considered not to be added to a race preparation or fat loss cycle. Its moderate estrogenicity makes it more suitable for the off-season muscle-building period, where the water storage property is more conducive to supporting training intensity and muscle size and helps promote a stronger anabolic environment.

Testosterone enanthate side effects: (androgenic side effects)

Testosterone is the primary male androgen responsible for the maintenance of secondary male sexual characteristics. Elevated testosterone levels may produce androgenic side effects, including oily skin due to sebaceous glands, acne, and body/facial hair growth. Men with a genetic predisposition to hair loss (male pattern baldness) may cause accelerated baldness. Those concerned about hair loss can use nandrolone decanoate (DECA Deca), which is a gentler steroid and a good option for those with hair loss. Women are particularly affected by steroids, especially strong androgenic steroids, such as testosterone. Androgens cause women to develop a number of androgenic traits, and these may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. In androgen-responsive target tissues such as the skin, scalp, and prostate, the androgenic effects of testosterone depend on how much is converted to dihydrotestosterone (DHT). 5-alpha reductase is responsible for this metabolism of testosterone. The concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride interferes with the site-specific enhancement of testosterone action and reduces the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that both anabolic and androgenic actions are mediated through cytosolic androgen receptors. Even with the use of 5-alpha reductase inhibition, it is not possible to completely separate the anabolic and androgenic properties of testosterone. Testosterone enanthate side effects: (hepatotoxicity) Testosterone has no hepatotoxic effects; hepatotoxicity is unlikely. One study examined the potential for hepatotoxicity of high doses of testosterone by administering 400 mg of the hormone daily (2,800 mg per week) to a group of male subjects. Oral steroids resulted in higher peak concentrations in liver tissue compared to intramuscular injections. Hormones were given daily for 20 days, and liver enzyme values, including serum albumin, bilirubin, alanine-aminotransferase, and alkaline phosphatase, were measured. No significant changes!

Testosterone enanthate side effects: (cardiovascular effects)

Anabolic/androgenic steroids can have a deleterious effect on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift HDL to LDL homeostasis, an abnormality which may cause and increase the risk of atherosclerosis. The effect of anabolic/androgenic steroids on lipids depends on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and cause left ventricular hypertrophy, all of which may increase the risk of cardiovascular disease and myocardial infarction. Compared to other steroid products, testosterone has a much smaller effect on cardiovascular risk factors. This is due to the openness of the liver to metabolism, which makes it less likely to affect liver cholesterol. Testosterone’s aromatization of estradiol also helps to mitigate the negative effects of androgens on blood lipids. In one study, 280 mg of testosterone ester (heptanoate) per week had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but a strong decrease (25%) was observed when administered with an aromatase inhibitor. In contrast, another study that used 300 mg of testosterone enanthate weekly for 20 weeks without an aromatase inhibitor showed only a 13% reduction in HDL cholesterol, while 600 mg of testosterone enanthate reduced it by up to 21%. The effect of aromatase inhibitors on lipids should be taken into account before using them. Because of the positive effects of estrogen on lipids, tamoxifen or clomiphene are superior to aromatase inhibitors for those associated with cardiovascular health because they provide some of the estrogenic effects in the liver. This allows them to potentially improve the lipid profile and counteract some of the negative effects of androgens. When using weekly amounts of 600 mg dose or less, the effects on lipids tend to be significant but not too severe, and the use of anti-estrogens may not be necessary. Doses of 600 mg per week or less also failed to produce significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all of which suggest relatively weak effects on cardiovascular risk factors. When used at moderate doses, testosterone is generally considered the safest of all anabolic/androgenic steroids. To help reduce cardiovascular strain as well as abnormal lipid levels, it is recommended to proactively maintain an active aerobic exercise program at all times during steroid use and to minimize intake of saturated fat, cholesterol, and simple carbohydrates. Supplementation with fish oil (4 grams per day) and natural cholesterol/antioxidant products is also recommended.

Testosterone Enanthate Side Effects: (HPTA Hypothalamic Suppression)

The use of exogenous testosterone inhibits the production of natural testosterone. For a patient with low testosterone, this is not a problem. Because his own testosterone production is already abnormal. For the athlete who is using steroids during the cycle phase, this is also irrelevant because the exogenous testosterone administered will provide your body with everything it needs. Once all anabolic steroid use is over, natural testosterone production will begin again. However, you will not return to normal overnight; it will take some time. Once use has ended, most people will begin a post-circulatory therapy (PCT) program. A quality and effective PCT program will include SERMs like tamoxifen (Nolvadex) and clomiphene (Clomid), and the peptide hormone HCG (human chorionic gonadotropin). Without a PCT program, you will recover, but it will take a lot of time. Since a chronic low testosterone state is the anabolic environment in which cortisol becomes the dominant hormone, the loss of muscle tissue in a catabolic state can be severe.

Testosterone enanthate side effects: (fertility problems)

The anabolic steroid AAS can disrupt the normal endocrine environment of the body during the use cycle, resulting in the disruption of sex hormone secretion, poor sperm quality, and low sperm count due to the imbalance of each hormone secretion, and azoospermia in large doses. In the process of use, because of the poor quality of sperm, the chance of conception will be very low; of course, the process of use should also do a good job of protection measures after the body to restore the normal endocrine, fertility problems can be restored.

Dosage of testosterone enanthate.

Used in medical treatment for androgen deficiency, prescribing guidelines for testosterone enanthate call for a dose of 50-100 mg every 2 to 4 weeks, despite prolonged in vivo activity. However, the usual dose used in bodybuilding for muscle growth or to enhance athletic performance is 200-600 mg per week, usually for 6 to 12 weeks. This level is sufficient for most people to notice a significant increase in muscle size and strength. Testosterone enanthate is often added to off-season muscle building, where the water storage from testosterone enanthate is irrelevant, and the user is more concerned with muscle growth than conditioning. It is also used by athletes as a basic maintenance of testosterone levels by adding it to their preparation cycle, but usually at a lower dose (100-200mg per week) and in conjunction with an aromatase inhibitor to control estrogen levels. Testosterone enanthate is a very effective anabolic drug, even when used alone. Most people stack it with other anabolic/androgenic steroids to get a stronger effect.

Testosterone enanthate works in the following ways.

Enhanced protein synthesis: Protein represents the main component of muscle tissue, and synthesis represents the rate at which cells build protein. By supplementing with testosterone enanthate, the rate of synthesis is enhanced. This promotes higher levels of anabolic activity and enhances the body’s ability to recover.

Enhanced Nitrogen Retention: By enhancing nitrogen retention, we protect the anabolic atmosphere and enhance it to some degree. All lean muscle tissue is composed of approximately 16% nitrogen, and when levels drop, this leads to a catabolic (muscle wasting) state. By maintaining a positive nitrogen balance, we maintain more anabolism. This will enhance tissue growth and is imperative when dieting to protect lean muscle tissue.

Increased Red Blood Cell Count: By increasing our red blood cell count, we greatly increase our muscular endurance. This is due to the fact that red blood cells are responsible for carrying oxygen and passing it through the bloodstream. Greater blood oxidation equates to greater output, more endurance, and even a role in recovery.

Increased IGF-1 Production: Insulin-growth factor-1 (IGF-1) is a naturally occurring protein hormone (peptide) that is produced primarily by the liver. This hormone is very anabolic and affects almost all cells in the body. It is also directly related to human growth hormone (HGH), as HGH primarily regulates its production. This hormone also plays a powerful role in the body’s ability to heal and restore muscle tissue, cartilage, nerves, tendons, ligaments, and even our central nervous system in many other areas.

Glucocorticoid Inhibition: Glucocorticoids are naturally occurring steroid hormones; however, they are not anabolic. In fact, glucocorticoids are catabolic (muscle atrophy), as they destroy muscle tissue and promote fat gain. Cortisol is the most well-known glucocorticoid or stress hormone, as they are often known. These hormones are necessary for the body to some degree, but not in large amounts. By suppressing these hormones, we again promote a stronger anabolic environment in the body.

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