Deca Durabolin
Androgen Index 37
Anabolic Index 125
Maternal Hormone Testosterone
Chemical Name 19-norandrost-4-en-3-one-17beta-ol, 17beta-hydroxy-estr-4-en-3-one Estrogenic
Activity Low
Progesterone Activity Medium
Deca Durabolin Introduction:
Deca Durabolin (nandrolone decanoate) is one of the most commonly used anabolic steroids among bodybuilders. It is known to be a very effective off-season vitamin-enhancing steroid, but it is also favored by many in the athletic community for its therapeutic effects. Due to its tremendous therapeutic benefits, the nandrolone family of hormones is one of the most beneficial anabolic steroids in medical practice. However, due to years of controversy over anabolic steroids, this medical use has been very limited in the United States for many years. Outside of the United States, Decadron is still more popular in treatment programs that can cover many areas. Deca dorabolin is also known as nandrolone decanoate. Nandrolone decanoate provides a slow release of nandrolone from the injection site that lasts up to three weeks. The structure of nandrolone is very similar to testosterone, although it does not have a carbon atom at the 19th position (hence its alternative name of 19-nortestosterone). Like testosterone, nandrolone exhibits relatively strong anabolic properties. However, unlike testosterone, whose tissue-building activity is accompanied by weak androgenic properties, the mild properties of nandrolone decanoate make it one of the most popular injectable steroids worldwide. Deca Durabolin has a relatively potent anabolic rating, slightly higher than testosterone. However, its total androgenic activity is much lower than testosterone, with an androgenic rating of only 37. The reduced androgenic activity of Deca compared to testosterone 100 is due to the hormone’s ability to be reduced to DHN rather than dihydrotestosterone (DHT). . This makes daidzein Durabolin milder than testosterone and one of the most tolerated anabolic steroids in healthy adult males. This tolerable nature is also evident by its low estrogenic activity. Diekadophorin has an aromatizing effect but only about 20% of testosterone. However, it has strong progestogenic properties, which will produce side effects, as we will see later.
Doca product effects:
Like many anabolic steroids, Deca can enhance protein synthesis, inhibit glucocorticoids and promote enhanced IGF-1 output. Deca also can increase nitrogen retention in the muscle, but it appears to have a stronger impact than many steroids in this regard. Studies have shown that even low doses of nandrolone can greatly increase the ability to retain nitrogen. This is an important factor, as all muscle tissue contains about 16% nitrogen. While this may sound small, the more we retain, the more anabolic we retain. When nitrogen levels are too low and unbalanced, this can cause us to enter a catabolic (muscle atrophy) state. Decadron is also known for carrying two important properties: increasing bone mineral content and enhancing collagen synthesis, and largely separating it from many anabolic steroids.
Similarly, many other steroids will carry these properties, but Decadron is more pronounced for both. Because of these characteristics, Decadron is also known for promoting relief of joint stress, and for many athletes, this is the only reason they use it. Due to these characteristics, as well as its ability to increase red blood cell counts, we can begin to see what types of therapeutic benefits this steroid can have. As an off-season bulking steroid, dexadolaparin will significantly increase body weight, but the increase in muscle mass will increase slowly. This is a large ester-based steroid, which will not work quickly. However, compared to many anabolic steroids, the weight gain caused by the use of Doka tends to be the most, and most people should also find that their strength increases to a certain extent, and of course, there is some relationship with water storage, but it is fairly easy to control.
Deca Durabolin Structural Characteristics
Deca Durabolin (nandrolone decanoate) is a modified form of nandrolone in which decanoic acid has been attached to the 17-beta hydroxyl group. The esterified steroid is less polar than the free steroid and is absorbed more slowly from the injection area. Once in the bloodstream, the ester is removed, and free (active) nandrolone is obtained. Nandrolone decanoate provides a sharp peak release within 24-48 hours after deep intramuscular injection, and it gradually declines to near baseline levels after about two weeks. The half-life of nandrolone decanoate is 7-12 days.
Deca Pharmacokinetics
Bioavailability Oral: <3% (pigs)
Intramuscular: 53-73%
Metabolic pathway Blood (hydrolysis), liver (reduction)
Metabolites
- 5α-Dihydronandrolone
- 19-Norandrosterone
- 19-Noretiocholanolone
- Conjugates
Half-life 6-12 days
Duration Intramuscular injection 2-3 weeks
Route of excretion Urine
Noretiocholanolone Decanoate Product History:
Nandrolone Decanoate (Deca-Dorabolin) was first mentioned in development in 1960 and became a prescription drug in 1962. It was developed by international pharmaceutical giant Organon and marketed under the brand name Deca-Durabolin. Deca-Durabolin indicates that the product contains a variant of Organon’s formerly popular nandrolone injectable Durabolin (nandrolone phenylpropionate) using a 10-carbon atom ester. Organon quickly expanded the market for nandrolone decanoate after its release. It is likely that Deca-Durabolin quickly became one of the most widely distributed anabolic steroids in the world due to its favorable properties and the large market presence of Organon. When first introduced to the United States, nandrolone decanoate (as Durabolin) was used to treat various conditions. Indications listed included preoperative and postoperative use to establish lean body mass, osteoporosis, advanced breast cancer, weight loss due to rehabilitation or disease, geriatric states (generalized weakness and frailty), burns, severe trauma, ulcers, adjunctive treatment of certain forms of anemia, and selective cases of growth retardation in children.
Due to the very low recommended dose (usually 50-100 mg every 3-4 weeks), the drug was sold only in doses of 50 mg/ml. The drug was soon updated to include a 100mg/ml version, reflecting the need for higher doses in some cases, particularly those with refractory anemia and advanced breast cancer. Subsequently, although the drug had been heavily used for numerous medical purposes for about a decade, by the mid-1970s, the indicated use of nandrolone decanoate was refined in the United States and abroad. The FDA approved prescribing information in 1975, listing nandrolone decanoate as a “potentially effective” adjunctive treatment for age-related and postmenopausal osteoporosis and treating pituitary insufficiency in dwarfism until growth hormone became more readily available. It is also considered “potentially effective” in helping to preserve lean body mass, control advanced breast cancer, and as an adjunctive treatment for certain types of anemia. There is more time to study this drug’s potential “less effective” uses. Modern (approved) medical applications of the drug are even more refined than in the mid-1970s. The FDA currently approves the drug only for treating anemia in the United States. However, it is also often used “off-label” to protect lean body mass in HIV-positive patients and others with wasting disease. Outside the U.S., Organon appears to support the use of this drug primarily for patients with severe anemia, osteoporosis, and advanced breast cancer. Nandrolone decanoate under the Organon Deca-Durabolin brand is still widely available today and is now distributed by the new parent company Merck/MSD. In addition, nandrolone decanoate is manufactured as a generic drug in many countries and is also produced under many other unique brands for human and veterinary use.
Nandrolone Decanoate (Deca) Side Effects: Estrogen
Deca has a slight aromatization. Aromatization refers to the ability to convert testosterone to estrogen, which occurs due to the interaction of hormones with aromatase enzymes. As estrogen levels rise, this can promote feminine breasts in men, excessive water retention, and hypertension due to severe water retention. Fortunately, Dieka has low levels of aromatase, but there is another factor to consider, and that is its progestational nature. Nandrolone has a strong affinity for progesterone receptors and can significantly stimulate estrogenic mechanisms in breast tissue, thereby increasing the risk of gynecomastia. Notably, nandrolone has some activity in vivo as a progestin. While progesterone is a C-19 steroid, many C-19 anabolic steroids have also shown some affinity for the progesterone receptor. Side effects associated with progesterone are similar to those of estrogen, including inhibition of the HPTA hypothalamus and lipid storage. Progesterone also enhances the stimulatory effect of estrogen on breast tissue growth. There is also a strong synergistic effect between these two hormones, so gynecomastia may be catalyzed by progesterone synergy without excessive estrogen levels. Anti-estrogen use is often sufficient to reduce gynecomastia caused by nandrolone.
Nandrolone Decanoate (Deca) Side Effects: Androgenic
Generica can produce androgenic side effects; however, for most men, the threshold tends to be quite high, with essentially 99% not returning and only a small percentage of sensitive individuals possibly causing possible androgenic side effects of Generica including acne, accelerated hair loss in male pattern baldness and hair loss in body hair growth. This side effect depends heavily on genetic predisposition, but most men should find no problems. Unlike testosterone, nandrolone is reduced to DHN rather than DHT, and although this occurs due to interaction with 5-alpha reductase, it greatly reduces the androgenic effects of nandrolone. An important note on the androgenic side effects of daidzein or any nandrolone hormone: Many people choose to use 5-alpha reductase inhibitors such as finasteride to counteract the androgenic side effects caused by anabolic steroids. However, instead of reducing the effects, using 5-alpha reductase inhibitors can exacerbate the androgenic properties of Deca.
Nandrolone Decanoate (Deca) Side Effects: Cardiovascular System
Deca may negatively affect cholesterol by reducing the HDL to LDL ratio. This potential negative effect is most prominent because it is associated with HDL cholesterol suppression. Studies have shown that nandrolone has a stronger effect on HDL cholesterol than testosterone. However, the effects on the cardiovascular system, as well as lipids, are much lower than those of most oral steroids. Due to the potential cholesterol problems caused by daidzein, it will be very important to maintain a cholesterol-friendly lifestyle during its use. You should avoid high-cholesterol diets in your daily diet while consuming omega-rich foods and maintaining a good frequency of aerobic exercise. If you use aromatase inhibitors (anastrozole, letrozole, exemestane, etc., AI drugs) while using dextran, you need to pay more attention to your cholesterol levels.
Nandrolone Decanoate (Dexamethasone) side effects: Self-testosterone production suppression
All nandrolone-based steroids are more extreme for auto-testosterone secretion. Some studies have shown that serum testosterone levels are reduced by at least 2/3 after a single 100mg dose of Deca. Other studies, while not showing near suppression rates, are still significant, so all cycles using Deca should add exogenous testosterone to prevent a low testosterone state.
Nandrolone Decanoate (Deca) Side Effects: Hepatotoxicity
Deca is non-toxic to the liver and does not cause stress or damage vital organs.
Dosage of Deca:
Deca is a very slow-acting steroid that does not require frequent injections. In most treatment protocols, Deca is administered only every 2-4 weeks and, more commonly, every 3-4 weeks. Of course, some more frequent ones are for anemia; when treating anemia, Deca is usually administered once a week. For athletes, once-weekly injections would be appropriate. However, some people will split it into two smaller injections per week to reduce the total amount of injections. The standard dose range for Generica is typically 100mg every 2-4 weeks for basal therapy and 100-200mg per week for anemia. For athletes, 100mg per week is a good starting point, but most will be more than happy with the great benefits of 200mg per week. Such a dose will enhance recovery, relief, and endurance and provide a slight anabolic boost. For true anabolic gains, 300mg per week is usually considered the low end of the dose spectrum. Many will find that 400mg per week is the perfect dose level and, more importantly, within manageable levels. Many men may tolerate doses as high as 600mg per week. However, this increases the risk of adverse reactions, and 400mg per week is usually more than adequate, and Deca should not be used for less than eight weeks on a schedule. Deca is very slow acting due to adding the decanoic acid lipid chain, so it needs to be used for a long time to get the most benefit. Eight weeks should be the minimum, but once discontinued, Deca will still be active in the body for several weeks.
